WORK WITH US
HEAL YOUR GUT PROGRAM

The Healthy Gut Blog

Discover the connection between your gut and overall well-being on The Gut Matters Blog. Read our articles on digestive health, nutrition, functional medicine, and the mind-body connection. Dr. Gundle provides evidence-based information and actionable advice to empower you on your journey to optimal health.

The Gut–Helicobacter pylori Connection: What You Need to Know for Long-Term Digestive Wellness

Jun 21, 2025

If you’ve been quietly dealing with persistent bloating, stubborn reflux, or a kind of fatigue that doesn’t respond to sleep or supplements, it’s easy to assume the cause is stress, age, or just bad luck.

Many of the women I work with arrive at that exact conclusion until testing uncovers something they hadn’t considered: Helicobacter pylori.

Helicobacter pylori, often abbreviated as H. pylori, is a common bacterium that can colonize the stomach lining. It’s estimated that nearly half the global population carries it, though many people never develop symptoms. For those who do, H. pylori can trigger a cascade of issues that affect digestion, nutrient absorption, and overall gut integrity. While often overlooked, it may be the root cause behind symptoms you’ve learned to live with.

Standard medical testing doesn’t always pick up H. pylori, particularly when symptoms are vague or chronic. Many women receive inconclusive results, especially when conventional panels don’t reveal obvious inflammation. In these cases, advanced microbial testing, such as functional stool analysis, can identify microbial imbalances or inflammatory byproducts that point to a lingering H. pylori infection or its lasting effects.

For those who prefer to learn by listening or watching, this video on H. pylori testing and natural alternatives, part of my Mind Body Monday series, explains how the bacterium is typically detected, why standard tests can fall short, and what functional tools we use instead, including stool testing and breath analysis.

I also share four natural interventions that I often turn to in practice. These options go beyond conventional antibiotics and offer support for those who either can't tolerate standard therapies or want to pursue a more holistic path. Whether you’re looking for botanical options, supportive supplements, or ways to rebuild the microbiome post-treatment, the video offers a grounded starting point—and helps clarify when treatment is essential and when a more watchful, supportive approach may be enough.

For a bacterium so common, H. pylori has a surprisingly complex relationship with the gut. According to the Mayo Clinic, about 50 percent of those infected may remain asymptomatic for life. That’s one reason routine treatment isn’t always recommended. But when symptoms are present, or when the infection is found during a workup for digestive complaints, intervention may be necessary.

The signs of an active infection aren’t always dramatic. In some cases, there’s a persistent sense of stomach discomfort that flares up with stress or fasting. For others, it shows up as bloating after meals, unexplained nausea, appetite changes, or burping that doesn’t go away. In more advanced cases, H. pylori can contribute to peptic ulcers and has been associated with a higher risk of stomach cancer if left untreated.

What’s often overlooked is how it affects the balance of the gut microbiome. Infections may lead to a reduction in beneficial bacteria, including Bifidobacterium and Lactobacillus, while promoting inflammation and gut permeability. Even after the infection clears, these effects can linger and create long-term digestive challenges.

The standard treatment protocol usually involves a combination of antibiotics and proton pump inhibitors, or PPIs. These medications can help eradicate the bacteria, but the process doesn’t end there. In fact, many patients continue to experience symptoms like bloating and indigestion long after finishing treatment.

The gut has a memory, and when its microbiome has been disrupted by both infection and antibiotics, it needs support to fully recalibrate.

That’s why in my practice, I focus not only on detection and removal but on recovery. Functional stool testing often reveals ongoing inflammation, leaky gut, or diminished microbial diversity even in patients who have technically cleared H. pylori. This insight helps guide a deeper healing strategy rather than relying on a one-size-fits-all solution.

Diagnosing H. pylori can involve several methods. A urea breath test, which measures carbon dioxide after drinking a special solution, is commonly used. Stool tests can detect bacterial antigens in feces and are especially helpful for ongoing monitoring.

Blood tests, which were once a primary tool, are now less relied upon because they may only show past exposure rather than current infection. In some cases, an upper endoscopy may be recommended to allow for biopsy and direct visual assessment of the stomach lining.

According to Johns Hopkins Medicine, conventional treatment includes dual or triple antibiotic therapy, often involving medications like amoxicillin, clarithromycin, or metronidazole. PPIs such as omeprazole or lansoprazole are used alongside to reduce stomach acid and promote healing. Bismuth subsalicylate, known commercially as Pepto-Bismol, may also be added to provide a protective coating for the stomach lining and increase the bacterium’s vulnerability.

But eliminating the bacterium isn’t the same as healing the gut.

Long-term recovery requires a stepwise, personalized approach. In my clinical practice, that process begins with a focus on repairing gut barrier function. That may include using targeted botanicals and nutrients to support the lining of the stomach and small intestine. After acute treatment, rebuilding the microbiome becomes essential. Reintroducing beneficial microbes through fermented foods and strain-specific probiotics can help restore microbial balance and support immune regulation. It’s equally important to feed these beneficial bacteria with prebiotic fibers, which are found in whole grains, legumes, and vegetables.

Lab tracking plays a critical role in this phase. Monitoring iron, B12, and stomach acid levels helps us catch and correct nutrient deficiencies that are often overlooked but deeply impactful. Without enough stomach acid, for instance, your body can’t absorb key nutrients—even if your diet is solid.

There’s another layer that often gets missed in clinical conversations, and that’s the role of stress. Chronic stress alters the gut’s environment, reducing enzyme output, compromising blood flow, and contributing to dysbiosis. Mindfulness practices, physical movement, and prioritizing rest aren’t lifestyle luxuries. They’re necessary components of gut recovery.

If you’ve been managing chronic digestive symptoms with little clarity on the cause, it may be time to consider H. pylori testing. The infection may be active, or its imprint may still be affecting your microbiome. Testing is especially relevant if you’ve experienced ulcers, long-term PPI use, persistent reflux, iron-deficiency anemia, or unresolved gut issues after travel or foodborne illness.

Healing from H. pylori isn’t just about removing the bad. It’s about restoring the good. That means rebuilding the ecosystem of the gut and supporting your body’s ability to regulate, absorb, and protect itself. In my practice, we don’t rush that process. We build it thoughtfully with data, strategy, and care.

If you’re curious about how this kind of gut disruption could be linked to other issues, like skin flare-ups or acne, I explore that connection in detail in this article on the gut–skin connection.

If you’re ready to explore what’s beneath the surface of your digestive health, I invite you to connect. My team and I specialize in guiding patients through complex gut challenges with a personalized, holistic approach. You don’t have to live with vague answers or temporary fixes. A healthier, more resilient gut is possible, and it starts with understanding the full story.

Visit TheGutHealthSpecialists.com to book a consultation and take your next step toward lasting digestive wellness.

THE GUT MATTERS BLOG

Want Helpful Health Tips Every Week?

Many people refuse to stay informed until an illness comes knocking. Join our email community to stay up to date with your Gut matters!

You're safe with me. I'll never spam you or sell your contact info.

Dr. Gundle | The Heal Your Gut Program

Success Stories | Symptoms

Gut Matters Blog

Contact us | Gut Education

FAQs | Glossary | Privacy | Terms